CAS · 58-27-5
Product Overview
Menadione is a high-purity vitamins supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade: | USP32 |
|---|---|
| Appearance: | Bright yellow, crystalline, practically odorless powder. Is affected by sunlight. Practically insoluble in water; soluble in vegetable oils; sparingly soluble in chloroform and in alcohol. |
| Assay: | 98.5% to 101.0% |
| Identification: | A: Infrared Absorption B: Ultraviolet Absorption |
| Melting range: | 105℃ to 107℃ |
| Loss on drying: | 0.3% max |
| Residue on ignition: | 0.1% max |
| Ordinary impurities: | Conforms |
| Heavy metal (Pb): | 20 ppm max |
| Cr: | 50 ppm max |
| As: | 2 ppm max |
| Ethyl alcohol: | 5000 ppm max |
Applications
1. Animal Feed Additive (Veterinary Use)
Menadione丨58-27-5 is primarily used as a vitamin K supplement in animal nutrition.
● Promotes Blood Coagulation: Supports the synthesis of prothrombin and other clotting factors in livestock and poultry.
● Improves Growth and Health: Enhances bone metabolism and overall resilience, particularly in chickens, pigs, fish, and pets.
● Formulations: Often provided in the form of menadione sodium bisulfite (MSB) or menadione nicotinamide bisulfite (MNB) to improve stability and bioavailability.
2. Nutraceutical and Pharmaceutical Use (Limited/Historic)
● Synthetic Vitamin K Source: Menadione has historically been used as a vitamin K supplement for humans, though it is no longer recommended due to potential toxicity.
● In some contexts, it is still investigated or used under medical supervision for:
Hemorrhage control
Antidote for anticoagulant poisoning (e.g., warfarin overdose) – though vitamin K1 (phylloquinone) is now preferred.
3. Research and Industrial Applications
● Biochemical Research: Used to study oxidative stress, redox cycling, and cellular responses to reactive oxygen species (ROS).
● Synthetic Intermediate: Menadione serves as a starting material in the synthesis of other quinones, vitamins, and pharmaceutical compounds.
● Photocatalysis and Dye Chemistry: Its conjugated structure makes it useful in certain photo-induced or electron-transfer processes.
Benefits
1. Essential Role in Blood Clotting
● Functions as a vitamin K precursor, necessary for the post-translational modification of proteins involved in blood coagulation, bone formation, and vascular health.
2. Cost-Effective and Stable
● Menadione丨58-27-5 is more stable and economical to produce than natural vitamin K1 or K2, making it suitable for use in bulk animal feed.
● Derivatives of menadione exhibit improved water solubility and shelf life, enhancing ease of formulation.
3. Promotes Animal Welfare and Productivity
● Improves bone strength, growth rates, and disease resistance in farmed animals and aquaculture, contributing to more sustainable animal husbandry practices.
4. Research Utility
● Menadione is widely used in laboratories to study oxidative stress, as it generates ROS through redox cycling.
● Helpful in cancer research, cell biology, and pharmacology as a model compound to evaluate antioxidant defenses and mitochondrial responses.
Conclusion
Menadione丨58-27-5 is a synthetic compound with structural similarity to vitamin K, playing a vital role in animal nutrition, biochemical research, and industrial applications. Though no longer used in human supplementation due to safety concerns, its importance in veterinary health, particularly for blood coagulation and bone metabolism, remains significant. Its stability, cost-effectiveness, and biological activity make menadione a valuable tool in both science and agriculture.
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Conclusion
A concise summary and suitability assessment for this product is available on request. Contact our team to discuss whether it fits your process and quality requirements.