CAS · 13734-41-3
Product Overview
Boc-L-Valine is a high-purity nutrient-additives supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Property | Specification |
|---|---|
| Appearance | White or Off-white crystalline powder |
| Content | 98.5~101.0% |
| Purity (HPLC) | 99% min |
| Melting Point | 71~84°C |
| Solubility | Clear and colorless |
| Specific Rotation | -5.8° to -6.8° (C=1, AcOH) |
| Loss on Drying | 0.5% max |
| Individual Impurity | 0.3% max |
Applications
1. Peptide Synthesis
● Boc-L-Valine丨CAS 13734-41-3 is extensively used in solid-phase peptide synthesis (SPPS) and solution-phase synthesis.
● It introduces L-valine into growing peptide chains while the Boc group protects the amino group during coupling reactions.
● Widely used in research, pharmaceutical development, and bioactive peptide production.
2. Pharmaceutical Intermediates
● Serves as an intermediate in the manufacture of peptide-based drugs, enzyme inhibitors, and other biologically active molecules.
● Used in the development of HIV protease inhibitors, antibiotics, and anticancer agents.
3. Custom and Modified Peptides
● Valuable in synthesizing modified peptides with bulky side chains (isopropyl group) for conformational studies or binding optimization.
● Helps researchers explore structure-activity relationships (SAR) in drug discovery.
4. Chiral Building Block
● As an enantiomerically pure molecule, Boc-L-Valine is used in asymmetric synthesis to prepare chiral intermediates.
● Supports the development of enantiomerically pure compounds in medicinal and agrochemical applications.
Benefits
1. Excellent Protecting Group Compatibility
● The Boc group is stable under neutral and basic conditions but easily removed with acids (e.g., TFA), allowing selective deprotection.
● Facilitates orthogonal protection strategies in complex peptide and organic syntheses.
2. High Purity and Stereochemical Integrity
● Commercially available in high optical purity, making it reliable for use in stereoselective synthesis.
● Maintains the correct chirality of L-valine, crucial for biological activity.
3. Bulky Side Chain for Structural Control
● The isopropyl side chain of valine provides steric hindrance, useful in:
Enhancing peptide secondary structure (e.g., β-turns or helices)
Preventing racemization
Improving enzyme resistance in peptide drugs
4. Ease of Handling and Solubility
● Stable, non-hygroscopic solid that is easy to handle in lab environments.
● Soluble in a range of organic solvents, making it compatible with many synthesis protocols.
Conclusion
Boc-L-Valine丨CAS 13734-41-3 is a highly valuable reagent in peptide chemistry and organic synthesis, offering both synthetic flexibility and stereochemical precision. Its robust Boc protection, high purity, and compatibility with modern synthesis techniques make it indispensable in pharmaceutical R&D, biological studies, and chemical manufacturing.
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