CAS · 79069-13-9
Product Overview
N-Boc-L-alaninol is a high-purity amino-acids supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Property | Specification |
|---|---|
| Appearance | White or off-white crystalline powder |
| Purity (by GC) | 98.0% min |
| Identification | HNMR |
| Water Content | 0.5% max |
| Specific Rotation | -8° to -10° |
Applications
1. Pharmaceutical Intermediate
● Chiral Building Block: N-Boc-L-alaninol丨CAS 79069-13-9 serves as a chiral intermediate in the synthesis of pharmaceuticals and bioactive molecules. It maintains the stereochemistry of L-alanine while allowing selective modification due to its protected amino group and free hydroxyl group.
● Often used in the synthesis of:
Peptidomimetics
Beta-amino alcohol derivatives
Heterocyclic drug precursors
2. Peptide and Peptoid Synthesis
● The Boc group protects the amino functionality during solid-phase peptide synthesis (SPPS) or solution-phase synthesis, preventing side reactions and allowing stepwise coupling of amino acid residues.
● The hydroxyl group can participate in:
Cyclization reactions
Oxidation to aldehydes or acids
Conversion to other functional groups for diversification
3. Organic Synthesis
● Used as a nucleophile or starting material for complex ligands, chiral auxiliaries, or catalysts.
● Useful in making oxazolines, amino alcohols, and other heterocycles relevant to drug discovery and asymmetric synthesis.
4. Biochemistry Research
● Employed in biochemical research where a protected amino alcohol is needed to mimic parts of natural peptides while retaining stability and controllability in synthetic routes.
Benefits
1. Protective Group Strategy
● The Boc group is widely used in organic synthesis due to its:
Stability under neutral and basic conditions
Ease of removal under mild acidic conditions (e.g., TFA)
2. Chirality Retention
● Derived from L-alanine, it offers optical purity and chiral integrity, making it suitable for enantioselective synthesis of pharmaceuticals and fine chemicals.
3. Dual Functionality
● The combination of an alcohol and a protected amine provides synthetic flexibility, enabling a wide variety of chemical transformations.
4. High Purity and Reactivity
● Commercially available in high purity, making it reliable for precise synthesis in regulated environments such as pharma R&D and manufacturing.
Conclusion
N-Boc-L-alaninol丨CAS 79069-13-9 is a valuable protected chiral amino alcohol used extensively in peptide synthesis, chiral drug development, and advanced organic synthesis. Its combination of a Boc-protected amine and a free hydroxyl group offers chemists a robust and flexible intermediate for building complex molecules with high stereochemical fidelity.
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