CAS · 27527-05-5
Product Overview
L-Cyclohexylalanine is a high-purity amino-acids supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White to off-white solid |
|---|---|
| Assay | 98% min |
| Specific rotation | 11–14° (c=1, 1N HCl) |
| Loss on drying | 0.5% max |
| Residue on ignition | 0.2% max |
| Non-animal origin | Confirms |
Applications
L-Cyclohexylalanine (CAS 27527-05-5) is a non-proteinogenic amino acid widely used in peptide synthesis, medicinal chemistry, and biochemical research. It is incorporated into peptides and peptidomimetics to modify hydrophobicity, steric bulk, and conformational behavior, often improving binding affinity and selectivity toward biological targets. The compound is frequently applied in the design of enzyme inhibitors, receptor ligands, and peptide-based drug candidates, particularly where enhanced metabolic stability is desired. In addition, L-cyclohexylalanine is used in structure–activity relationship studies to evaluate the impact of bulky hydrophobic side chains on peptide folding, bioactivity, and resistance to enzymatic degradation. It also serves as a chiral building block in the synthesis of complex pharmaceutical intermediates.
Benefits
The benefits of L-cyclohexylalanine arise from its well-defined stereochemistry, strong hydrophobic character, and structural rigidity. The cyclohexyl side chain increases steric bulk and lipophilicity, which can enhance target binding and improve peptide stability against proteolysis. Its L-configuration ensures compatibility with standard peptide synthesis methods and predictable incorporation into biologically active sequences. The compound is chemically stable, easy to handle, and compatible with common coupling reagents used in solid-phase and solution-phase peptide synthesis. These features make it an effective tool for fine-tuning peptide properties and optimizing the pharmacological profile of peptide-based compounds.
Conclusion
L-Cyclohexylalanine is a valuable non-natural amino acid used in peptide synthesis and medicinal chemistry to enhance hydrophobicity, stability, and biological performance. Its bulky cyclohexyl side chain and defined chirality support the design of robust and selective peptides and pharmaceutical intermediates. By enabling structural optimization and improved bioactivity, L-cyclohexylalanine continues to play an important role in peptide research and drug development.
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