CAS · 913733-27-4
Product Overview
Fmoc-N-Me-Arg(Pbf)-OH is a high-purity amino-acids supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White powder |
|---|---|
| Purity (HPLC, 210 nm) | 95.0% min. |
| Optical Purity | 99% min. |
| Water Content (K. F.) | Report |
| Mass Spectrum | In accordance with the structure |
| NMR Spectrum | In accordance with the structure |
Applications
Peptide Synthesis
Fmoc-N-Me-Arg(Pbf)-OH is utilized in Fmoc-based solid-phase peptide synthesis (SPPS) to incorporate Nα-methylated arginine residues into peptides. The Pbf (2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl) group serves as a protective group for the guanidino side chain, which can be removed under mild conditions, facilitating the synthesis of peptides with complex structures.
Drug Development
This amino acid derivative is employed in the development of peptide-based therapeutics, including inhibitors targeting specific enzymes or receptors. For instance, it has been used to synthesize tetrapeptide aldehyde inhibitors of dengue virus NS3 protease, showcasing its potential in antiviral drug development.
Research Applications
Fmoc-N-Me-Arg(Pbf)-OH is a valuable tool in research settings for the synthesis of peptides with modified pharmacological properties. It aids in the exploration of structure-activity relationships and the development of novel peptide-based probes for biological studies.
Benefits
Enhanced Stability
The Nα-methylation of the arginine residue imparts increased stability to the peptide backbone, reducing susceptibility to proteolytic degradation and enhancing the pharmacokinetic properties of the resulting peptides.
Selective Cleavage
The Pbf protecting group allows for selective and mild cleavage conditions, minimizing the risk of side reactions and preserving the integrity of the peptide during synthesis.
Versatility in Peptide Design
The incorporation of Nα-methylated arginine residues enables the design of peptides with improved binding affinity and specificity for their targets, expanding the potential applications in therapeutic and diagnostic fields.
High Purity and Quality
Available in high purity forms (typically ≥95%), ensuring consistent performance in synthetic applications and reliable results in subsequent biological assays.
Conclusion
Fmoc-N-Me-Arg(Pbf)-OH (CAS 913733-27-4) is a specialized amino acid derivative that plays a crucial role in the synthesis of peptides with enhanced stability and specificity. Its applications in drug development and research underscore its importance in advancing peptide-based therapeutics and diagnostics. The benefits of improved stability, selective cleavage, and versatility make it an indispensable tool in the field of peptide chemistry.
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