CAS · 220497-61-0
Product Overview
Fmoc-Cpg-OH is a high-purity amino-acids supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White powder |
|---|---|
| Purity (HPLC) | 98% min |
| Optical Purity | 0.5% D-enantiomer max |
| Specific Rotation [α]20/D | -18.5 ± 2° (C=2 in DMF) |
| Melting Point | 180-190°C |
| Clarity of solution | 0.3 g in 2 mL DMF, clear solution |
| Water Content (K.F.) | 1.0% max |
| Loss on Drying | 1.0% max (80°C, 2h) |
| IR Spectrum | In accordance with the structure |
| Mass Spectrum | In accordance with the structure |
| NMR Spectrum | In accordance with the structure |
Applications
Fmoc-Cpg-OH is primarily used as a protected amino acid derivative in peptide synthesis and molecular biology research. The compound contains an Fmoc (9-fluorenylmethoxycarbonyl) protecting group, which allows selective incorporation into solid-phase peptide synthesis (SPPS) workflows while preventing unwanted side reactions at the amino terminus. It is commonly applied in the synthesis of peptides, peptidomimetics, and modified oligopeptides for pharmaceutical, biochemical, and diagnostic research. In laboratory settings, Fmoc-Cpg-OH is used to construct peptide sequences with specific functional residues, enabling the study of structure–activity relationships, enzyme interactions, and protein–ligand binding. The protected amino acid also facilitates the development of specialized peptides for therapeutic, analytical, and biomolecular applications.
Benefits
Fmoc-Cpg-OH offers several advantages due to its Fmoc protection and defined chemical structure. The Fmoc group provides stable and removable protection under mild basic conditions, allowing precise control over peptide chain elongation. Its high purity and reproducibility support reliable and consistent results in solid-phase synthesis. The compound is compatible with common solvents, resins, and coupling reagents, simplifying handling and integration into established SPPS protocols. Additionally, its defined stereochemistry ensures accurate incorporation into peptides, preserving biological activity and enabling predictable performance in downstream assays or applications. These properties make it a convenient and dependable intermediate for peptide research and development.
Conclusion
Fmoc-Cpg-OH is a valuable protected amino acid for use in peptide synthesis and biochemical research. Its applications in SPPS, peptidomimetic construction, and molecular studies, combined with benefits such as stable protection, high purity, and predictable incorporation, make it an essential tool for the production of functional peptides. The compound continues to support advances in therapeutic development, analytical research, and peptide-based experimental studies.
Previous
H-D-Trp(Boc)-OH丨CAS 201290-11-1
Next