CAS · 1262886-65-6
Product Overview
Fmoc-(S)-2-aminononanoic acid is a high-purity amino-acids supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White powder |
|---|---|
| Purity | 98% min |
| Water content | 1.0% max |
Applications
Fmoc-(S)-2-aminononanoic acid (CAS 1262886-65-6) is a protected amino acid widely used in peptide synthesis and medicinal chemistry. The Fmoc (9-fluorenylmethyloxycarbonyl) group protects the amino functionality, allowing selective coupling reactions in solid-phase or solution-phase peptide synthesis. This compound is employed in the preparation of custom peptides, peptidomimetics, and biologically active sequences, where the nonanoic acid side chain introduces hydrophobicity and conformational influence. It is also used in the synthesis of lipidated peptides, enzyme inhibitors, and other therapeutic molecules that require a defined stereochemistry and protection strategy for efficient assembly. Its versatility makes it a key building block in pharmaceutical research and peptide-based material development.
Benefits
The benefits of Fmoc-(S)-2-aminononanoic acid derive from its combination of stereochemical purity, protection, and synthetic accessibility. The Fmoc protecting group is stable under neutral and mildly basic conditions, allowing stepwise peptide assembly without unwanted side reactions, and can be removed under mild basic conditions to expose the free amine. The (S)-enantiomer ensures precise stereochemical control, which is critical for biological activity in peptide therapeutics. The nonanoic acid moiety contributes hydrophobic interactions, influencing peptide folding, stability, and membrane permeability. Overall, it enables efficient, high-fidelity peptide synthesis with predictable structural and functional outcomes.
Conclusion
In summary, Fmoc-(S)-2-aminononanoic acid is an essential intermediate in peptide synthesis and medicinal chemistry. Its applications include solid-phase and solution-phase peptide assembly, lipidated peptide preparation, and therapeutic molecule development. Its benefits lie in stereochemical fidelity, Fmoc protection, and influence on peptide properties, making it a reliable building block for precise and functional peptide design.
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