CAS · 69004-04-2
Product Overview
Toltrazuril sulfone is a high-purity veterinary-medicine supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | White to off-white crystalline powder, odorless |
|---|---|
| M.P: | 242~246 °C |
| Solution: | Clear and colourless |
| Related substances | |
| Single impurity: | 1.0% max |
| Total impurities: | 2.0% max |
| Loss on drying: | 0.5% max |
| Assay (C18H14F3N3O6S) (dried base): | 98% min |
Applications
1. Veterinary Medicine
Antiprotozoal Agent: Highly effective against protozoan parasites such as Eimeria, Isospora, Sarcocystis, Neospora caninum, and Toxoplasma gondii.
Coccidiosis Treatment: Used for the prevention and treatment of coccidiosis, particularly in young animals like piglets, calves, and poultry.
Equine Protozoal Myeloencephalitis (EPM): In horses, Ponazuril (Toltrazuril sulfone) is the primary treatment for Sarcocystis neurona, a key causative agent of EPM, a serious neurological disease.
Pet Health: Applied in treating Cystoisospora (formerly Isospora) infections in puppies and kittens.
2. Research Use
Studied for its effects on protozoal metabolism and cell division, especially for developing new antiprotozoal drugs.
Used in laboratory models to investigate toxoplasmosis and neosporosis.
Benefits
Long-Acting Effect: Due to its extended half-life, a single dose or short course is often sufficient for effective treatment.
Broad-Spectrum Activity: Targets multiple protozoan species at various stages of development (schizonts, gamonts).
High Selectivity: Interferes with nuclear division and mitochondrial function of protozoa without significantly affecting host cells.
Well Tolerated: Demonstrates a good safety profile in most animal species when administered at recommended doses.
Oral Availability: Suitable for oral administration via paste, suspension, or feed premix.
Conclusion
Toltrazuril sulfone (CAS 69004-04-2), commonly known as Ponazuril, is a highly effective and selective antiprotozoal agent widely used in veterinary medicine. Its broad-spectrum activity, long-lasting effect, and favorable safety profile make it a preferred choice for the treatment and prevention of protozoan infections such as coccidiosis and equine protozoal myeloencephalitis. As a key tool in animal health, it continues to play a vital role in improving productivity, welfare, and disease control in both companion and livestock animals.
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