5-Bromo-3,4-dimethylpyridin-2-amine

5-Bromo-3,4-dimethylpyridin-2-amine is a high-purity pesticide-intermediate supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

5-Bromo-3,4-dimethylpyridin-2-amine is a specialized heterocyclic intermediate widely used in medicinal chemistry, agrochemical development, and organic synthesis. Its brominated pyridine core provides a reactive site for cross-coupling reactions such as Suzuki, Buchwald–Hartwig, and Sonogashira reactions, enabling the introduction of diverse substituents and the construction of complex heterocyclic frameworks. In drug discovery, it is applied to synthesize analogs of pyridine-containing pharmaceuticals, including kinase inhibitors, antibacterial agents, and CNS-active compounds, where the amino and methyl groups contribute to binding affinity and molecular stability. The compound is also employed in agrochemical research for the development of herbicides, insecticides, and fungicides, as the pyridine scaffold is a common motif in active molecules. Additionally, it is utilized in the preparation of functionalized pyridine derivatives for material science applications, chemical probe synthesis, and library generation for high-throughput screening, supporting structure–activity relationship studies and multi-step synthetic pathways.

This compound offers significant advantages in synthetic chemistry due to its reactive bromine atom and amino functionality. The bromine enables selective carbon–halogen bond transformations under mild conditions, facilitating efficient cross-coupling and substitution reactions. The presence of the amino group allows for further derivatization, including acylation, sulfonylation, and alkylation, expanding its versatility in molecular design. The dimethyl substitution on the pyridine ring enhances chemical stability, solubility, and electronic properties, which can improve reaction efficiency and selectivity. Its solid, stable form simplifies storage, handling, and incorporation into synthetic workflows. Furthermore, it provides a reliable and predictable platform for multi-step synthesis, reducing purification complexity and supporting rapid generation of structurally diverse derivatives for pharmaceutical and agrochemical development.

5-Bromo-3,4-dimethylpyridin-2-amine is a valuable heterocyclic intermediate for medicinal chemistry, agrochemical synthesis, and advanced organic research. Its brominated pyridine core, amino functionality, and dimethyl substitutions combine to offer high reactivity, versatility, and stability, making it ideal for cross-coupling reactions and multi-step synthesis. By enabling efficient functionalization and the creation of diverse derivatives, it supports drug discovery, agrochemical innovation, and the development of functionalized heterocycles, contributing to faster research, higher yields, and more effective molecular design.

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