CAS · 514-36-3
Product Overview
Fludrocortisone acetate is a high-purity fluorescein supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade: | EP 8.0 |
|---|---|
| Appearance: | White or almost white crystalline powder |
| Assay: | 97% to 103% |
| Solubility: | Practically insoluble in water; sparingly soluble in anhydrous ethanol |
| Specific Rotation: | +148° to +156° |
| Loss on Drying: | 1% max |
| Residual Solvent: | DMF: 880 ppm max |
| Related Substances: | |
| The Biggest Impurity: | 1% max |
| Total Impurities: | 1.5% max |
Applications
Fludrocortisone acetate (CAS 514-36-3) is a synthetic corticosteroid with potent mineralocorticoid activity, primarily used in the treatment of adrenal insufficiency, including Addison's disease and congenital adrenal hyperplasia. It is also used to manage orthostatic hypotension and certain salt-wasting conditions by helping the body retain sodium and maintain electrolyte balance. Fludrocortisone acetate is commonly administered orally in tablet form, providing precise dosing for long-term hormone replacement therapy. In clinical research, it is utilized to study mineralocorticoid effects, electrolyte regulation, and cardiovascular responses in both healthy subjects and patients with endocrine disorders.
Benefits
The benefits of fludrocortisone acetate stem from its high potency and dual glucocorticoid/mineralocorticoid activity. Its mineralocorticoid action helps regulate sodium and water balance, preventing hypotension and electrolyte imbalances in patients with adrenal insufficiency. This allows for improved cardiovascular stability and overall patient well-being. Its glucocorticoid effects also provide mild anti-inflammatory benefits, supporting physiological hormone replacement. The oral formulation ensures ease of administration, consistent absorption, and effective long-term management of chronic endocrine disorders, reducing the risk of complications associated with adrenal hormone deficiency.
Conclusion
Fludrocortisone acetate is a potent corticosteroid with essential applications in managing adrenal insufficiency and related disorders. Its ability to regulate electrolyte balance and provide hormone replacement makes it invaluable in clinical practice. By supporting cardiovascular stability and overall endocrine health, fludrocortisone acetate remains a key therapeutic agent in the treatment and management of mineralocorticoid-related conditions.
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