CAS · 34381-71-0
Product Overview
N-Methyl-L-prolinol is a high-purity amino-acid supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Light yellow liquid |
|---|---|
| Assay: | 98% min |
| IR, HNMR: | Conforms |
| EE value: | 99% min |
Applications
1. Asymmetric Catalysis and Organic Synthesis
N-Methyl-L-prolinol is primarily used as a chiral building block and a ligand or organocatalyst in asymmetric synthesis.
● Organocatalysis: Used in enantioselective reactions such as aldol, Mannich, or Michael additions. It can mimic the catalytic role of L-proline while offering modified reactivity due to its N-methyl group.
● Chiral Ligand or Auxiliary: Incorporated into transition-metal complexes or organocatalysts to control stereochemistry in the synthesis of pharmaceuticals and fine chemicals.
2. Pharmaceutical Intermediate
Due to its chiral and functionalized nature, N-Methyl-L-prolinol is used as an intermediate in the synthesis of active pharmaceutical ingredients (APIs).
● Peptidomimetics and Small Molecules: Used to synthesize structures where proline derivatives are required to maintain or induce bioactive conformations.
● Stereocontrolled Drug Synthesis: Helps in constructing complex molecules with specific 3D orientations, especially in neuroactive compounds or antivirals.
3. Agrochemical and Fine Chemical Synthesis
N-Methyl-L-prolinol丨34381-71-0 is also used in the preparation of biologically active molecules outside the pharmaceutical realm.
● Crop Protection Agents: Chiral intermediates like N-Methyl-L-prolinol are often part of synthetic routes for fungicides, herbicides, and growth regulators.
● Flavors and Fragrances: Occasionally used in the design of chiral flavoring agents due to its biocompatible structure.
4. Research and Development
● Stereoselective Method Development: Frequently employed in R&D labs to develop or test new enantioselective methodologies.
● Biomimetic Chemistry: Its similarity to natural amino acids allows it to serve as a tool for modeling biological reaction mechanisms or enzyme behavior.
Benefits
1. Chiral Purity and Enantioselectivity
● Available as the L-enantiomer, which is essential for asymmetric synthesis and ensures high enantioselectivity in catalytic reactions.
● A reliable source of stereochemistry, enabling the creation of optically active compounds with biological relevance.
2. Dual Functional Groups
● The presence of both an alcohol (-OH) and a secondary amine (-NH) group in a five-membered ring provides versatile reactivity for different types of chemical transformations.
● Useful in hydrogen bonding, nucleophilic catalysis, and coordination with metal ions.
3. Biocompatibility and Low Toxicity
● As a derivative of L-proline, a natural amino acid, N-Methyl-L-prolinol丨34381-71-0 generally exhibits low toxicity and biocompatibility, making it favorable for pharmaceutical and biological research.
4. Stability and Processability
● It is chemically stable under standard storage conditions.
● Easily handled in lab and industrial environments, with good solubility in organic solvents and water, enhancing its utility in multi-step synthesis.
Conclusion
N-Methyl-L-prolinol丨34381-71-0 is a valuable chiral amino alcohol with wide-ranging applications in asymmetric synthesis, pharmaceutical development, and fine chemical manufacturing. Its combination of functional groups and enantiomeric purity makes it an essential tool for researchers and synthetic chemists working on stereochemically complex molecules. As demand grows for precise and efficient enantioselective processes, compounds like N-Methyl-L-prolinol will continue to play a key role in modern chemical innovation.
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Conclusion
A concise summary and suitability assessment for this product is available on request. Contact our team to discuss whether it fits your process and quality requirements.