CAS · 144690-92-6
Product Overview
Trityl olmesartan is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | White to off-white solid |
|---|---|
| Purity (HPLC): | 98% min |
| Maximum single impurity: | 1.0% max |
| Water: | 0.5% max |
| Residue on ignition: | 0.5% max |
Applications
1. Pharmaceutical Intermediate
Intermediate for Olmesartan Medoxomil Synthesis:
Trityl olmesartan is specifically used in the late-stage synthesis of olmesartan medoxomil. It helps protect the tetrazole moiety or other sensitive groups during reactions such as acylation, esterification, and hydrolysis.
Used in GMP Manufacturing:
It is handled under Good Manufacturing Practices (GMP) conditions to ensure purity, yield, and consistency in the production of cardiovascular drugs.
2. Research and Development
Synthetic Route Development:
Employed in medicinal chemistry and pharmaceutical R&D to optimize the synthetic pathway of ARBs or design olmesartan analogs.
Quality Control and Validation:
Used as a reference compound in analytical method development and impurity profiling during the quality assurance process for olmesartan APIs.
Benefits
Facilitates Selective Reactions: The trityl group allows chemists to protect sensitive functional groups during synthesis, minimizing side reactions and degradation.
Improves Synthesis Yield and Purity: The use of trityl olmesartan in the synthesis process enhances the overall yield and ensures high-purity production of olmesartan medoxomil.
Enables Industrial-Scale Production: Its stability and specificity make it suitable for scale-up in commercial manufacturing of antihypertensive medications.
Essential for Regulatory Compliance: Intermediate traceability and characterization are required for regulatory filings like DMFs and CEPs in pharmaceutical production.
Conclusion
Trityl olmesartan (CAS 144690-92-6) is a critical protected intermediate in the synthesis of olmesartan medoxomil, an important antihypertensive drug. Its function in safeguarding reactive groups and enabling high-yield production processes underpins its importance in pharmaceutical manufacturing and R&D. As demand for ARBs remains high globally, trityl olmesartan continues to be a valuable compound in the supply chain of modern cardiovascular therapeutics.
Previous
(S)-(-)-4-Bromo-alpha-phenylethylamine丨CAS 27298-97-1
Next