CAS · 13472-35-0
Product Overview
Sodium dihydrogen phosphate dihydrate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade: | EP9.6 |
|---|---|
| Appearance: | White or almost white powder or colourless crystals |
| Assay: | 98.0% to 100.5% (calculated on the dried basis) |
| Solubility: | Very soluble in water, very slightly soluble in ethanol (96%) |
| Identification A: | Solution S is slightly acid |
| B: | Solution S gives reaction of phosphates |
| C: | Solution S gives reaction (a) of sodium |
| Tests Appearance of solution: | Solution S is clear and colourless |
| pH: | 4.2 to 4.5 |
| Reducing substances: | The color of the permanganate is not completely discharged |
| Chlorides: | 200 ppm max |
| Sulphates: | 300 ppm max |
| Arsenic: | 2 ppm max |
| Iron: | 10 ppm max |
| Loss on drying: | 21.5% ~ 24.0% |
Applications
1. Buffering Agent in Laboratories and Industry
● Commonly used in phosphate buffer systems:
o pH control in biochemical and chemical reactions
Component of PBS (phosphate-buffered saline)
● Especially important in enzyme assays, cell culture, and electrophoresis
● Acts as a primary phosphate donor when mixed with disodium phosphate for fine-tuning pH
2. Pharmaceutical Applications
● Used as a laxative or osmotic agent in some oral preparations
● Serves as a buffer or excipient in:
Intravenous solutions
Eye drops
Injectable medications
● Maintains acid-base balance in formulations
● Generally recognized as safe (GRAS) in regulated uses
3. Food Industry (Additive and pH Regulator)
● Sodium dihydrogen phosphate dihydrate丨CAS 13472-35-0 functions as a food additive (E339):
Acts as a leavening agent, emulsifier, and acidity regulator
Common in baked goods, dairy products, processed cheese, and beverages
● Helps retain moisture and texture in meats and seafood
4. Water Treatment
● Used to prevent scale and corrosion in water systems by:
Controlling pH
Sequestering calcium and magnesium ions
● Can be part of formulations for boiler water conditioning
5. Agriculture and Fertilizers
● Occasionally used in foliar sprays or fertilizer blends to supply phosphorus, a vital macronutrient for plant growth
● Aids in soil pH stabilization and nutrient uptake
6. Analytical and Diagnostic Applications
● Used in analytical chemistry as a reagent and standard buffer
● Maintains stable pH in biological assays, titrations, and colorimetric tests
Benefits
1. Excellent Buffering Capacity
● Provides stable and predictable pH control, especially in the acidic to neutral range
● Compatible with a variety of biological systems
2. High Solubility in Water
● Dissolves readily, allowing for easy preparation of aqueous buffer systems
● Ensures uniform distribution in food, pharmaceuticals, and lab solutions
3. Safe and Non-toxic
● Low toxicity and GRAS status for food and pharmaceutical use
● Non-hazardous under normal handling conditions
4. Hydrated Form Enhances Stability
● The dihydrate form offers:
Improved crystallization
Longer shelf life
Reduced hygroscopic behavior compared to anhydrous form
5. Multifunctional
● Useful in cross-disciplinary applications: from life sciences to materials processing
● Combines buffering, hydration, ion balance, and stabilization functions
Conclusion
Sodium dihydrogen phosphate dihydrate丨CAS 13472-35-0 is a highly versatile, water-soluble, and biocompatible phosphate salt. Its wide-ranging applications in buffer preparation, pharmaceutical formulations, food processing, and water treatment highlight its value in both industrial and laboratory settings. With a proven safety profile and excellent functional characteristics, it is an essential component in many biological, chemical, and manufacturing processes.
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