CAS · 6018-19-5
Product Overview
Sodium 4-aminosalicylate dihydrate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Off-white or light yellow powder |
|---|---|
| Assay: | 99% min |
| Identification: | Positive reaction |
| Solution color and clarity: | Complies |
| Loss on drying: | 16.0–17.5% |
| pH: | 6.5–8.5 |
| Chloride: | 0.005% |
| Sulfate: | 0.05% max |
| Heavy metal content: | 10 ppm max |
| Fe: | 15 ppm max |
| m-Aminophenol: | 0.05% max |
Applications
Sodium 4-aminosalicylate dihydrate is an important pharmaceutical compound primarily used as an antitubercular agent. It serves as the sodium salt form of para-aminosalicylic acid (PAS), which inhibits the synthesis of folic acid in Mycobacterium tuberculosis, thereby suppressing bacterial growth. It is typically employed as part of a combination therapy with other first- or second-line drugs such as isoniazid, rifampicin, and ethambutol to prevent the development of drug resistance. Beyond its antituberculosis role, it is also used in pharmaceutical research as a model compound to study drug metabolism, pharmacokinetics, and anti-inflammatory mechanisms. In certain formulations, it acts as a stabilizing and buffering agent due to its sodium salt form, which improves solubility and absorption characteristics.
Benefits
The dihydrate form of sodium 4-aminosalicylate provides enhanced chemical stability and better aqueous solubility compared to its free acid counterpart, allowing for more consistent bioavailability and reduced gastric irritation. It is well tolerated in most patients and contributes effectively to multi-drug regimens that limit the emergence of resistant tuberculosis strains. The compound exhibits both anti-inflammatory and antimicrobial properties, making it valuable in reducing inflammation in the gastrointestinal tract and respiratory tissues during infection. Its reliable efficacy, compatibility with other medications, and established safety record make it a trusted therapeutic agent in clinical practice.
Conclusion
Sodium 4-aminosalicylate dihydrate remains a vital component in the treatment of tuberculosis and related infections. Its dual antibacterial and anti-inflammatory properties, combined with excellent solubility, stability, and therapeutic compatibility, make it indispensable in modern multidrug therapies. The compound's pharmaceutical reliability continues to support global efforts in controlling and managing tuberculosis effectively.
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