CAS · 13682-77-4
Product Overview
Potassium vinyltrifluoroborate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White to off-white powder |
|---|---|
| Purity | 97% min |
| QNMR | 95% min |
| 1H NMR | δ ppm 5.82-5.70 (m, 1 H), 5.11-5.05 (m, 2 H) |
| Solubility - DMSO | 25 mg/ml min |
| Solubility - MeOH | 25 mg/ml min |
| Residue on ignition | 0.5% max |
| Water | 1.0% max |
Applications
Potassium vinyltrifluoroborate (CAS 13682-77-4) is an organoboron compound widely used as a reagent and intermediate in organic synthesis, particularly in cross-coupling reactions. Its primary applications include serving as a vinyl source in Suzuki–Miyaura coupling reactions to construct carbon–carbon double bonds, enabling the synthesis of complex molecules such as pharmaceuticals, agrochemicals, and fine chemicals. It is also utilized in the preparation of functionalized alkenes, heterocycles, and polymer precursors. Its stability, ease of handling, and water solubility make it an attractive alternative to traditional vinylboronic acids or esters in synthetic chemistry.
Benefits
The benefits of potassium vinyltrifluoroborate stem from its chemical stability, reactivity, and versatility. Unlike many boronic acids, it is air- and moisture-stable, allowing safe storage and handling in the laboratory. Its reactivity in palladium-catalyzed cross-coupling reactions provides high yields and selectivity under mild conditions. Additionally, the trifluoroborate group improves solubility and reduces protodeboronation side reactions, ensuring reproducible and efficient transformations. These properties make it a valuable tool for synthesizing complex molecules with precise control over structure and functionality.
Conclusion
In conclusion, potassium vinyltrifluoroborate is a reliable and versatile organoboron reagent for modern organic synthesis. Its stability, reactivity, and compatibility with cross-coupling methods make it ideal for producing pharmaceuticals, fine chemicals, and advanced materials. By enabling efficient and selective carbon–carbon bond formation, it plays a key role in contemporary synthetic and medicinal chemistry.
Previous
Benzylhydroxylamine Hydrochloride丨CAS 2687-43-6
Next