CAS · 106627-54-7
Product Overview
N-Hydroxysulfosuccinimide sodium salt is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Off-white to white powder |
|---|---|
| Purity (HPLC) | 98% min |
| Melting Point | 300℃ min |
| Loss on Drying | 0.5% max |
| Identification by HNMR | Conforms to Structure |
Applications
N-Hydroxysulfosuccinimide sodium salt (sulfo-NHS) is a water-soluble derivative of N-hydroxysuccinimide widely used in bioconjugation, biochemical research, and pharmaceutical applications. It is primarily employed as an activator for carboxyl groups in aqueous media, enabling efficient coupling with amines to form stable amide bonds. This property makes it essential in the preparation of protein conjugates, antibody-drug conjugates (ADCs), peptide labeling, and immobilization of biomolecules on surfaces for diagnostics, biosensors, and affinity chromatography. Sulfo-NHS is also used in crosslinking reactions to stabilize protein complexes or modify biomolecules without the need for organic solvents, making it highly suitable for biological and pharmaceutical research where aqueous compatibility is critical.
Benefits
The benefits of sulfo-NHS stem from its water solubility, reactivity, and biocompatibility. Unlike its non-sulfonated counterpart, it can efficiently activate carboxyl groups in purely aqueous solutions, avoiding the use of toxic organic solvents and reducing denaturation of sensitive biomolecules. It promotes rapid and selective amide bond formation under mild conditions, preserving the biological activity of proteins, peptides, and other biomolecules. The reagent enhances conjugation efficiency, provides reproducible results, and enables the creation of stable, functional biomolecule conjugates for diagnostics, therapeutics, and research applications. Its compatibility with a wide range of biomolecules and aqueous systems makes it an indispensable tool in modern biochemical and pharmaceutical workflows.
Conclusion
In conclusion, N-Hydroxysulfosuccinimide sodium salt is a key reagent for bioconjugation, protein modification, and biomolecular research. Its applications include carboxyl group activation, peptide and protein labeling, antibody-drug conjugate synthesis, and surface immobilization of biomolecules, while its benefits include water solubility, biocompatibility, high reactivity, and mild reaction conditions. By combining versatility, efficiency, and compatibility with aqueous systems, sulfo-NHS continues to play a critical role in advancing biochemical research, diagnostics, and pharmaceutical development.
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