Methyl 2-bromo-5-chlorobenzoate

Methyl 2-bromo-5-chlorobenzoate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

1. Intermediate in Pharmaceutical Synthesis

Used as a building block in the synthesis of complex pharmaceutical compounds, particularly:

Substituted benzoates

Aryl esters with halogenated functional groups

The bromo and chloro groups enable selective cross-coupling reactions (e.g., Suzuki, Heck, or Stille) to introduce additional aryl or heteroaryl groups.

2. Agrochemical Intermediate

Employed in the preparation of fungicides, herbicides, and insecticides.

The electron-withdrawing halogens increase bioactivity and environmental stability of resulting compounds.

3. Material Science and Specialty Chemicals

Used as a precursor in the synthesis of functionalized materials, including liquid crystals, UV stabilizers, and fluorophores.

Ester group allows further conversion into acids, alcohols, or amides.

4. Cross-Coupling and Functionalization Studies

Widely used in organic synthesis research to study regioselective halogen displacement or functionalization.

A valuable substrate in structure-activity relationship (SAR) and library synthesis programs.

1. Dual Halogen Functionality (Br and Cl)

The presence of both bromo and chloro substituents allows orthogonal reactivity:

Bromine is more reactive in Pd-catalyzed cross-coupling.

Chlorine can be retained or functionalized selectively at later stages.

Enables stepwise synthesis of highly substituted aromatic compounds.

2. Synthetic Flexibility

The methyl ester group can be hydrolyzed to the carboxylic acid or converted to amides and alcohols, offering versatile downstream chemistry.

Compatible with a variety of nucleophilic and electrophilic reactions.

3. High Chemical Stability

Stable under standard conditions and easy to handle in laboratory and production settings.

Suitable for multi-step synthesis requiring intermediate purification and storage.

4. Commercial Availability

Readily available from chemical suppliers in both research-grade and bulk quantities, making it accessible for R&D and scale-up applications.

Methyl 2-bromo-5-chlorobenzoate (CAS 27007-53-0) is a halogenated benzoate ester used as a versatile intermediate in the synthesis of pharmaceuticals, agrochemicals, and functional materials. Its dual halogen groups enable selective functionalization in modern organic synthesis, while the ester functionality provides further synthetic flexibility. Its role in facilitating cross-coupling reactions and advanced aromatic substitution makes it a valuable compound in both academic and industrial chemistry.

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