Ethyl 6-chloronicotinate

Ethyl 6-chloronicotinate is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

1. Pharmaceutical Intermediate

Widely used as a building block in the synthesis of heterocyclic drug molecules, especially anti-infectives, anti-inflammatory, and oncology-related compounds.

Acts as a precursor for:

Nicotinamide-based drugs

Chloropyridine derivatives

Heterocyclic scaffolds with biological activity

2. Agrochemical Intermediate

Serves as an intermediate for the production of insecticides, herbicides, and fungicides.

The chlorinated pyridine ring enhances bioactivity and lipophilicity, making it ideal for the design of biologically active agrochemicals.

3. Fine Chemical Synthesis

Employed in the synthesis of specialty chemicals and research materials in organic and medicinal chemistry labs.

Useful in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) due to the presence of a halogen on the pyridine ring.

4. Material Science and Dyes (less common)

Pyridine esters like this compound may occasionally be used in the development of functional materials, including UV absorbers and electronic intermediates.

✅ Versatile Reactivity

The ester group allows for nucleophilic substitution, hydrolysis, and amidation.

The chlorine atom at the 6-position enables C–C and C–N coupling reactions, expanding synthetic possibilities.

✅ Good Stability and Handling

Stable under normal storage conditions.

Can be conveniently stored and used in lab and industrial environments.

✅ Useful in Combinatorial Chemistry

Enables rapid generation of compound libraries through derivatization, supporting drug discovery and lead optimization.

✅ Cost-Effective Building Block

Relatively low cost and commercially available in bulk quantities for scale-up applications.

Ethyl 6-chloronicotinate (CAS 49608-01-7) is a highly useful intermediate in organic synthesis, particularly in pharmaceutical and agrochemical development. Its dual reactivity from the ester and halogen groups makes it an ideal starting material for the production of complex, bioactive molecules, contributing to innovations in healthcare and crop protection.

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