CAS · 24277-39-2
Product Overview
Boc-L-glutamic acid 1-tert-butyl ester is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White or off-white powder |
|---|---|
| Purity (HPLC) | 98% min |
| Water | 0.5% max |
| Specific rotation (C=1 MeOH) | -28.0° ～ -32.0° |
| Melting point | 110℃ - 115℃ |
| Single impurity | 0.5% max |
Applications
In terms of applications, this compound is mainly used in the synthesis of peptides, peptidomimetics, and other bioactive molecules where controlled protection of functional groups is essential. The Boc group shields the amino group during coupling reactions, while the tert-butyl ester protects the side-chain carboxyl group, enabling selective deprotection and stepwise assembly of complex peptides. It is also employed in the preparation of chiral intermediates for pharmaceuticals, enzyme inhibitors, and other therapeutic agents. Its use ensures high stereochemical fidelity and reduces side reactions, which is critical in producing biologically active molecules with purity and efficiency.
Benefits
The benefits of Boc-L-glutamic acid 1-tert-butyl ester stem from its dual protecting groups, stereochemical stability, and versatility in synthetic chemistry. The Boc and tert-butyl ester groups can be selectively removed under mild conditions, facilitating multi-step synthesis without compromising the glutamic acid backbone. Its chirality ensures that resulting peptides or intermediates retain the desired enantiomeric configuration, which is important for biological activity. Additionally, it provides a reliable platform for functionalization at the amino or carboxyl sites, improving overall reaction efficiency and reproducibility. These properties make it a practical and valuable building block for both laboratory and industrial-scale peptide synthesis.
Conclusion
In conclusion, Boc-L-glutamic acid 1-tert-butyl ester is an important intermediate for peptide and bioactive molecule synthesis. Its applications in protecting functional groups and enabling stereochemically defined transformations, combined with benefits such as stability, selectivity, and synthetic flexibility, make it a key tool in pharmaceutical research and chemical development. The compound supports efficient, high-fidelity construction of complex molecular structures with wide-ranging applicability in modern medicinal chemistry.
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