CAS · 131707-23-8
Product Overview
Arbidol hydrochloride, with the Chemical Abstracts Service (CAS) number 131707-23-8, is an antiviral drug with the chemical name ethyl 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-1H-indole-3-carboxylate hydrochloride. It is a broad-spectrum antiviral agent primarily used for the prevention and treatment of influenza and other respiratory viral infections. Arbidol hydrochloride has gained attention for its potential activity against a range of viruses, including coronaviruses.
Product Specifications
| Property | Specification |
|---|---|
| Appearance | From white to white with a greenish-yellowish or brownish shade crystalline powder |
| Solubility | Sparingly soluble or slightly soluble in chloroform and ethanol 96%, practically insoluble in water |
| Identification | IR spectrum corresponds to the applied IR spectrum UV spectrum: Absorption at (225 ±2) nm, (255 ± 2) nm, and (316 ± 2) nm, with min. absorption at (244 ±2) nm and (284 ±2) nm Qualitative reaction of Chlorides and bromides |
| Related Impurities | Not more than 0.5% |
| Sulphated Ash | Not more than 0.1% |
| Heavy Metals | Not more than 0.001% |
| Water Content | From 3.0 to 4.0% |
| Residual Solvents | Acetone: Not more than 0.5% Ethanol: Not more than 0.5% |
| Assay | From 99.0% to 101.0% |
Applications
1. Influenza Treatment and Prevention:
- Arbidol hydrochloride is widely used in countries like Russia and China for the treatment and prophylaxis of influenza A and B viruses. It works by inhibiting viral fusion with host cell membranes, preventing viral entry and replication.
2. Respiratory Viral Infections:
- It has shown efficacy against other respiratory viruses, such as respiratory syncytial virus (RSV) and adenoviruses, making it a versatile antiviral agent.
3. Coronavirus Infections:
- Arbidol hydrochloride has been studied for its potential activity against coronaviruses, including SARS-CoV-2 (the virus responsible for COVID-19). It has been used in some countries as part of combination therapy for COVID-19, though its efficacy remains under investigation.
4. Immunomodulatory Effects:
- In addition to its antiviral properties, Arbidol hydrochloride has been reported to modulate the immune system, enhancing the body's antiviral response.
5. Research and Development:
- Arbidol hydrochloride丨131707-23-8 is used in antiviral research to study its mechanisms of action and potential applications against emerging viral pathogens.
Benefits
1. Broad-Spectrum Antiviral Activity:
- Its ability to target multiple viruses, including influenza and coronaviruses, makes it a valuable tool in combating respiratory viral infections.
2. Prophylactic Use:
- Arbidol hydrochloride can be used to prevent viral infections, particularly during outbreaks or seasonal influenza epidemics.
3. Low Resistance Development:
- Compared to other antiviral drugs, Arbidol hydrochloride has a lower likelihood of inducing viral resistance, making it a reliable option for long-term use.
4. Immunomodulatory Properties:
- Its ability to enhance immune responses may provide additional benefits in fighting viral infections.
5. Clinical Use:
- Arbidol hydrochloride丨131707-23-8 has been used clinically for decades in certain countries, with a well-established safety profile when used as directed.
Conclusion
Arbidol hydrochloride丨131707-23-8 is a broad-spectrum antiviral drug with applications in the treatment and prevention of influenza, respiratory viral infections, and potentially coronaviruses. Its ability to inhibit viral fusion and modulate the immune system makes it a valuable tool in antiviral therapy. While its safety profile is generally favorable, further research is needed to fully establish its efficacy, particularly against emerging viruses like SARS-CoV-2. As antiviral resistance and new viral threats continue to challenge global health, Arbidol hydrochloride remains a promising candidate for future therapeutic development.
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