CAS · 2237-30-1
Product Overview
3-Aminobenzonitrile is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Light yellow or reddish brown crystalline solid |
|---|---|
| Assay | 98.0% min |
| Drying loss | 0.05% max |
Applications
3‑Aminobenzonitrile (CAS 2237‑30‑1) is a widely used aromatic building block in organic and medicinal chemistry. It functions as an intermediate for the synthesis of heterocycles (e.g., aminobenzimidazoles, benzoxazoles, benzothiazoles), pharmaceutically relevant anilines and kinase‑inhibitor scaffolds, and agrochemical lead compounds. The compound is employed in dye and pigment manufacture, where further derivatization of the amino or nitrile group yields chromophoric systems, and in specialty‑chemical synthesis for ligands, corrosion inhibitors, and polymer additives. In method development and analytical chemistry it is used as a reference standard and as a probe substrate in catalytic coupling (Suzuki, Buchwald–Hartwig), nitrile‑functional group conversions, and selective functionalization studies.
Benefits
Its value comes from the combination of two complementary functional groups on the aromatic ring: a nucleophilic amino group and a versatile nitrile. The amino group enables acylation, alkylation, diazotization, and formation of heterocycles; the nitrile can be transformed into amides, carboxylic acids, tetrazoles, or reduced to amines, providing many divergent synthetic pathways from a single intermediate. This bifunctionality facilitates rapid SAR (structure–activity relationship) exploration in drug discovery and streamlined synthetic routes in process chemistry. 3‑Aminobenzonitrile is low‑molecular‑weight, chemically stable, and compatible with common solvents and catalytic systems, which simplifies handling, purification, and scale‑up.
Conclusion
3‑Aminobenzonitrile is a practical, high‑utility intermediate for constructing a broad array of bioactive molecules, heterocycles, dyes, and specialty materials. Its dual functional groups make it especially attractive for medicinal‑chemistry campaigns and multi‑step syntheses, enabling efficient diversification and predictable downstream transformations. As a stable, easy‑to‑handle building block, it supports rapid compound elaboration and scalable manufacturing workflows.
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