CAS · 446-52-6
Product Overview
2-Fluorobenzaldehyde is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Colorless liquid |
|---|---|
| Purity (GC) | 99.5% min |
| 4-Fluorobenzaldehyde | 0.05% max |
| 3-Fluorobenzaldehyde | 0.2% max |
| Free Acid | 0.3% max |
Applications
In terms of applications, 2-fluorobenzaldehyde is widely used as a building block in the preparation of active pharmaceutical ingredients, agrochemicals, fragrances, and specialty materials. Its reactive aldehyde group allows for participation in condensation, reduction, and cyclization reactions, enabling the synthesis of diverse complex molecules. The presence of the fluorine atom enhances metabolic stability and modulates electronic properties, making it useful in medicinal chemistry for designing drug candidates with improved activity or bioavailability. It is also employed in producing fluorinated alcohols, acids, heterocycles, and advanced intermediates used in research and industrial development. Beyond pharmaceuticals, it contributes to the manufacture of dyes, polymer additives, and fine chemicals requiring precise aromatic fluorination patterns.
Benefits
The benefits of 2-fluorobenzaldehyde arise from its structural versatility, predictable reactivity, and ability to introduce fluorinated functionality into target molecules. Fluorine substitution influences molecular behavior such as lipophilicity, binding affinity, and stability, which is highly advantageous in the development of optimized chemical compounds. Its aldehyde group facilitates efficient synthetic transformations, enabling high-yield pathways to valuable intermediates. The compound's relative stability and compatibility with common synthetic conditions make it convenient to handle in laboratory and industrial environments. In addition, its role in creating fluorinated derivatives supports innovation in pharmaceuticals and advanced materials, where fluorinated motifs can significantly enhance performance characteristics.
Conclusion
In conclusion, 2-fluorobenzaldehyde is an important aromatic intermediate used across pharmaceutical synthesis, agrochemical production, and specialty chemical manufacturing. Its combination of a reactive aldehyde group and strategically positioned fluorine atom provides significant flexibility in designing and constructing complex molecules. The benefits of improved synthetic efficiency, enhanced molecular properties, and wide-ranging applicability make it a key component in modern chemical research and industrial development.
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