CAS · 5329-12-4
Product Overview
2,4,6-Trichlorophenylhydrazine is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | Off-white powder |
|---|---|
| Purity | 99% min |
| Assay | 98% min |
| Loss on drying | 0.5% max |
| Melting point | 138–142 °C |
| Identification | The retention time of the test product was consistent with that of the control product in HPLC |
Applications
2,4,6‑Trichlorophenylhydrazine (CAS 5329‑12‑4) is primarily used as a specialized intermediate in organic and heterocyclic synthesis. It plays an important role in the preparation of substituted hydrazones, azo compounds, and nitrogen‑containing heterocycles, which are relevant in pharmaceutical and agrochemical research. The compound is often employed in medicinal chemistry for constructing key scaffolds used in lead discovery and structure–activity relationship studies, particularly where electron‑withdrawing chloro substituents are desired to modulate biological activity. In addition, 2,4,6‑trichlorophenylhydrazine is applied in dye and pigment chemistry, where it contributes to the synthesis of colorants and intermediates with enhanced stability. It is also used in laboratory research as a reagent for derivatization and mechanistic studies involving hydrazine functionality.
Benefits
The benefits of 2,4,6‑trichlorophenylhydrazine arise from its distinctive chemical structure and reactivity profile. The hydrazine functional group provides high nucleophilicity and versatility, enabling efficient condensation and coupling reactions with aldehydes, ketones, and activated electrophiles. The presence of three chloro substituents on the aromatic ring enhances chemical stability and electron‑withdrawing character, which can improve selectivity and control in synthetic reactions. This substitution pattern also allows fine‑tuning of physicochemical and biological properties in downstream compounds, making it valuable for targeted molecular design. From a synthetic standpoint, 2,4,6‑trichlorophenylhydrazine supports reproducible reactions and consistent product profiles, contributing to efficiency in both research and small‑scale industrial applications.
Conclusion
2,4,6‑Trichlorophenylhydrazine is a functional and versatile intermediate used mainly in pharmaceutical, agrochemical, and dye chemistry. Its combination of a reactive hydrazine group and a highly substituted aromatic ring enables the efficient synthesis of diverse nitrogen‑containing compounds with tailored properties. By offering reliability, structural control, and broad applicability, this compound remains a valuable tool for chemists engaged in advanced organic synthesis and research‑driven development.
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