CAS · 107873-03-0
Product Overview
2,2-Difluorocyclopropane-1-carboxylic acid is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White to light yellow solid powder |
|---|---|
| Purity (GC) | 98% min |
| Water | 0.5% max |
| Identification | Retention time of the sample conforms to that of the reference standard |
Applications
2,2-Difluorocyclopropane-1-carboxylic acid (CAS 107873-03-0) is a highly functionalized fluorinated building block widely used in medicinal chemistry and organic synthesis. Its cyclopropane ring, substituted with two fluorine atoms and a carboxylic acid group, provides unique steric and electronic properties that make it valuable in the design of bioactive molecules, including enzyme inhibitors, antiviral agents, and other pharmaceutical candidates. It is commonly employed in the synthesis of cyclopropyl-containing drug scaffolds, as well as in structure–activity relationship (SAR) studies, where the fluorinated cyclopropane moiety can modulate metabolic stability, lipophilicity, and receptor binding affinity. Additionally, it serves as a key intermediate in the preparation of heterocycles, amides, esters, and other functional derivatives in advanced organic synthesis.
Benefits
The benefits of 2,2-difluorocyclopropane-1-carboxylic acid stem from its unique combination of fluorination, ring strain, and carboxyl functionality. The difluorocyclopropyl group enhances metabolic stability and bioavailability when incorporated into drug molecules, while the carboxylic acid provides a versatile handle for coupling reactions, esterification, and amidation. Its small size and rigid structure enable precise spatial positioning in target molecules, improving receptor selectivity and potency. The compound is chemically stable, soluble in common organic solvents, and compatible with a wide range of reaction conditions, facilitating multi-step synthetic routes. These properties make it an indispensable tool for medicinal chemists seeking to design fluorinated cyclopropyl-containing drugs.
Conclusion
2,2-Difluorocyclopropane-1-carboxylic acid is a valuable fluorinated intermediate for the development of pharmaceuticals and advanced organic compounds. Its combination of difluorocyclopropyl and carboxyl functionality enables selective and efficient transformations, enhancing the stability, bioactivity, and synthetic versatility of target molecules. By providing structural rigidity and chemical adaptability, it continues to be a critical building block in modern drug discovery and medicinal chemistry research.
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