CAS · 13951-70-7
Product Overview
16alpha-Hydroxyprednisolone is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Description: | Off white to cream colour powder |
|---|---|
| Solubility: | Sparingly soluble in Methanol (0.1 g of sample in 10 mL of methanol) |
| Identification: | Conforms |
| Heavy Metals: | 20 ppm max |
| Loss on Drying: | 0.5% max |
| Related Substances (HPLC): | 1,2-Dihydro: 0.15% max Single impurity: 0.15% max 21-Acetate: 0.10% max Total impurities: 1.0% max |
| Assay (HPLC): | 98.0% min |
Applications
16α-Hydroxyprednisolone (CAS 13951-70-7) is a corticosteroid derivative primarily used as an intermediate in pharmaceutical synthesis. It serves as a key building block for the production of anti-inflammatory, immunosuppressive, and glucocorticoid drugs. Its hydroxylated structure at the 16α position allows for selective chemical modifications, enabling the synthesis of derivatives with improved pharmacological profiles, including enhanced potency, receptor selectivity, and reduced side effects. It is widely applied in medicinal chemistry for the development of corticosteroid analogs used in treating conditions such as asthma, autoimmune disorders, and allergic reactions.
Benefits
The benefits of 16α-Hydroxyprednisolone arise from its specific hydroxylation, which imparts increased chemical reactivity and biological relevance. The 16α-hydroxyl group enables targeted derivatization, such as esterification and conjugation, facilitating the design of drugs with optimized solubility, absorption, and metabolic stability. Its corticosteroid backbone maintains anti-inflammatory activity, while structural modifications reduce undesired mineralocorticoid effects. Additionally, the compound's stability and functional versatility make it a reliable intermediate in laboratory synthesis and industrial-scale pharmaceutical production.
Conclusion
16α-Hydroxyprednisolone is a valuable intermediate in corticosteroid drug development with key applications in medicinal chemistry and pharmaceutical synthesis. Its hydroxylated structure provides both chemical versatility and biological relevance, enabling the creation of potent and selective therapeutic agents. By supporting the synthesis of optimized corticosteroid derivatives, it remains an important tool in the development of anti-inflammatory and immunomodulatory medications.
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