1-(2,2-Difluoro-benzo1,3dioxol-5-yl)-cyclopropanecarboxylicacid
CAS 862574-88-7
CAS · 862574-88-7
Product Overview
1-(2,2-Difluoro-benzo1,3dioxol-5-yl)-cyclopropanecarboxylicacid is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | White to light brown solid |
|---|---|
| Assay (on anhydrous basis, by HPLC): | 98% - 102% |
| Purity: | 99% min |
| Cyclopropyl Carbonitrile: | 0.15% max |
| Nitrile Compound: | 0.15% max |
| Nitrile Acid Impurity: | 0.15% max |
| Any Other Individual Impurity: | 0.1% max |
| Total Impurities: | 1.0% max |
| Water: | 0.5% max |
| IR: | Match with corresponding wave numbers |
| Identification by HPLC: | The retention time of the acid compound in the chromatogram of the sample solution should correspond to that in the chromatogram of the standard solution, as obtained in the assay by HPLC |
Applications
1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylic acid (CAS 862574-88-7) is a fluorinated aromatic cyclopropane derivative primarily used as an intermediate in pharmaceutical and agrochemical synthesis. Its unique combination of a difluorobenzo[d][1,3]dioxole moiety and cyclopropanecarboxylic acid functionality allows for the construction of bioactive molecules with improved metabolic stability, lipophilicity, and receptor selectivity. In drug discovery, it is employed in the synthesis of enzyme inhibitors, receptor modulators, and other therapeutic candidates where fluorine incorporation enhances potency and pharmacokinetic properties. It is also used in agrochemical research for developing herbicides, fungicides, and insecticides, where fluorinated aromatics improve biological activity and chemical resilience.
Benefits
The benefits of 1-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylic acid arise from its fluorinated aromatic system and reactive carboxyl group. The difluoro substitution enhances chemical and metabolic stability, increases lipophilicity, and can improve binding affinity in biological targets. The cyclopropane ring provides steric rigidity, which contributes to selective interactions and structural stability in derivatives. Its carboxylic acid functionality enables straightforward derivatization through amide formation, esterification, or coupling reactions, making it a versatile building block for pharmaceuticals and agrochemicals. The combination of stability, reactivity, and bioactive potential makes it highly valuable in research and industrial synthesis.
Conclusion
1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylic acid is a versatile fluorinated intermediate with key applications in pharmaceutical and agrochemical development. Its structural features, including the difluoro aromatic ring and cyclopropane carboxylic acid moiety, provide stability, reactivity, and enhanced bioactivity. By enabling efficient synthesis of potent and metabolically stable compounds, it remains an important tool in drug discovery and chemical research.
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