1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.

This compound, commonly referred to as a DOTA-NHS ester, is a specialized chelating agent widely used in bioconjugation, radiopharmaceuticals, and molecular imaging applications. It is primarily employed to attach the DOTA chelator to biomolecules such as peptides, antibodies, or proteins through its reactive N-hydroxysuccinimide (NHS) ester group, forming stable amide bonds with amino groups. In nuclear medicine, the DOTA conjugates are used to chelate radiometals like ^68Ga, ^177Lu, or ^90Y, enabling targeted radiotherapy or diagnostic imaging (PET/SPECT). Additionally, it is applied in research for the preparation of metal-labeled biomolecules, enabling studies in pharmacokinetics, molecular targeting, and bio-distribution.

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester provides significant advantages due to its high reactivity, stability, and strong metal-chelating properties. The NHS ester enables selective and efficient conjugation to primary amines under mild conditions, preserving the biological activity of sensitive biomolecules. The DOTA chelator forms highly stable complexes with a wide range of radiometals, reducing metal release and improving safety in radiopharmaceutical applications. Its chemical stability, water solubility, and reproducibility make it suitable for laboratory synthesis, preclinical studies, and clinical applications. Furthermore, its versatility allows precise design of targeted imaging or therapeutic agents.

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester is a valuable reagent in bioconjugation, radiopharmaceutical development, and molecular imaging. Its benefits, including selective amine coupling, strong metal chelation, chemical stability, and versatility, make it an essential tool for the creation of targeted diagnostic and therapeutic agents. Continued use of this compound supports innovation in targeted radiotherapy, PET/SPECT imaging, and advanced biomedical research.

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