CAS · 27298-97-1
Product Overview
(S)-(-)-4-Bromo-alpha-phenylethylamine is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance: | Clear colorless to light yellow liquid |
|---|---|
| Identification by HNMR: | Structure confirmation |
| Identification by HPLC: | Retention time complies |
| Purity by HPLC (A%,λ=220nm): | 98% min |
| ee by HPLC: | 99% min |
| Water content (KF): | 0.5% max |
| Any other unspecified impurity: | 0.5% max |
| Metal Residue (Zn, Fe, Rh): | 20ppm max |
| Residue on ignition: | 0.3% max |
Applications
1. Pharmaceutical Intermediate
Chiral Building Block:
Used in the synthesis of chiral pharmaceutical agents, especially those targeting neurological or cardiovascular systems.
Precursor to Active Pharmaceutical Ingredients (APIs):
Acts as a key intermediate in the production of beta-adrenergic receptor ligands, CNS stimulants, or serotonin analogues.
2. Medicinal Chemistry and Drug Discovery
Template for Structure–Activity Relationship (SAR) Studies:
The compound's stereochemistry and halogen substitution make it ideal for exploring SAR in early-stage drug development.
Synthesis of Chiral Amines:
Useful in preparing other optically pure amines via asymmetric synthesis, resolution, or derivatization.
3. Neurochemical and Biological Research
Analog of Neuroactive Compounds:
Related in structure to phenylethylamines, a class of compounds known for modulating neurotransmitters like dopamine and serotonin.
Use in Behavioral and Pharmacological Studies:
Investigated for its effects or analogues' potential effects on mood, alertness, and neurological pathways in preclinical models.
Benefits
Chirally Pure:
Being the (S)-enantiomer, it provides better selectivity and specificity in chiral synthesis, particularly for biologically active compounds.
Functional Versatility:
The bromine group offers a handle for further substitution (e.g., via cross-coupling reactions), making it ideal for structural modification.
High Synthetic Value:
As a scaffold for new molecular entities (NMEs), it enables medicinal chemists to develop analogs with desired pharmacological profiles.
Research Relevance:
Valuable in studying structure-function relationships in bioactive amines and evaluating enantioselective pharmacokinetics.
Conclusion
(S)-(-)-4-Bromo-α-phenylethylamine (CAS 27298-97-1) serves as a crucial chiral intermediate in the synthesis of biologically active compounds and pharmaceutical research. Its halogenated aromatic structure and optical purity make it ideal for use in medicinal chemistry, SAR studies, and the development of neuroactive agents. As the demand for chirally pure drug molecules continues to rise, compounds like this remain vital tools in drug discovery and chemical biology.
Previous
Next