CAS · 42437-96-7
Product Overview
(R)-3-Quinuclidinol hydrochloride is a high-purity pharmaceutical-intermediates supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White or light yellow powder |
|---|---|
| Assay | Calculated as anhydrous substance, the content of C7H14ClNO should be between 98%-101% |
| Specific rotation | -30° ~ -40° |
| Water content | 1% max |
| Residue on ignition | 0.3% max |
| Isomers | 0.5% max |
Applications
(R)-3-Quinuclidinol hydrochloride is a chiral intermediate widely used in pharmaceutical synthesis and asymmetric catalysis. Its rigid bicyclic quinuclidine structure, combined with the hydroxyl group, makes it a valuable building block for the preparation of enantiomerically pure drugs, including central nervous system (CNS) agents, beta-blockers, and cholinergic modulators. It is also employed in the synthesis of chiral ligands and organocatalysts for asymmetric reactions, where its stereochemistry facilitates high enantioselectivity. In medicinal chemistry, (R)-3-Quinuclidinol hydrochloride serves as a precursor for biologically active heterocycles and piperidine derivatives, enabling the development of compounds with potent pharmacological activity. Its stability, solubility in polar solvents, and defined stereochemistry make it suitable for both laboratory-scale synthesis and industrial pharmaceutical production.
Benefits
The benefits of this compound derive from its chiral integrity, structural rigidity, and chemical versatility. As a chiral building block, it ensures high enantiomeric purity in the synthesis of active pharmaceutical ingredients, which is critical for safety, efficacy, and regulatory compliance. Its rigid bicyclic framework provides steric control in asymmetric reactions, enhancing selectivity and reducing by-products. The hydroxyl group allows diverse chemical modifications, including esterification, etherification, and coupling reactions, enabling the synthesis of a wide variety of functionalized derivatives. Additionally, the hydrochloride salt form improves handling, stability, and solubility in polar reaction media, facilitating efficient and reproducible reactions. These properties make (R)-3-Quinuclidinol hydrochloride a highly reliable and versatile intermediate for pharmaceutical research, asymmetric synthesis, and chiral ligand development.
Conclusion
In summary, (R)-3-Quinuclidinol hydrochloride is an essential chiral intermediate in pharmaceutical and asymmetric synthesis. Its applications in enantiomerically pure drug synthesis, chiral ligand preparation, and biologically active heterocycle development, combined with benefits such as high stereochemical fidelity, structural rigidity, and chemical versatility, make it indispensable in modern medicinal chemistry. By supporting efficient, selective, and reproducible synthetic strategies, it continues to play a critical role in drug discovery, asymmetric catalysis, and chemical research.
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