CAS · 9003-11-6
Product Overview
Poloxamer 182 is a high-purity pharmaceutical-excipients supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Grade | Pharmaceutical Grade |
|---|---|
| Appearance | Colourless to pale yellow viscous liquid |
| Average molecular weight | 1700～3200 |
| Ethylene oxide | 0.0001% max |
| Propylene oxide | 0.0005% max |
| 1,4-dioxane | 0.0005% max |
| Ethylene glycol | 0.01% max |
| Diethylene glycol | 0.01% max |
| Triethylene glycol | 0.01% max |
| Water | 0.4% max |
| Cloud point | 22.0～26.0 °C |
| Acidity or alkalinity (pH) | 5.0 min ～ 7.5 max |
| Chrominance | 50 max |
| Residue on ignition | 0.4% max |
| Heavy metal | 20 ppm max |
| Arsenic | Conform to regulations (0.0002%) |
| Microbial limits - Total aerobic bacteria | 10³ cfu/g max |
| Microbial limits - Mold and yeast | 10² cfu/g max |
Applications
Poloxamer 182 is widely used as a nonionic surfactant and emulsifying agent in pharmaceutical, cosmetic, and industrial formulations. In pharmaceutical applications, it is employed to enhance solubility, stabilize suspensions, and improve the delivery of poorly water-soluble drugs in oral, topical, and parenteral formulations. The compound is also used in personal care products such as creams, lotions, and cleansers, where it functions as a solubilizer and formulation stabilizer. In industrial and laboratory settings, Poloxamer 182 is applied in detergents, coatings, and processing aids, as well as in research involving colloidal systems, micelle formation, and formulation optimization.
Benefits
Poloxamer 182 offers several advantages due to its amphiphilic block copolymer structure. It provides effective surface activity, enabling efficient emulsification and stabilization of oil–water systems. The compound exhibits good biocompatibility and low toxicity, supporting its use in pharmaceutical and cosmetic products. Its ability to form micelles enhances the solubilization of hydrophobic substances, improving formulation performance and consistency. Poloxamer 182 is chemically stable over a wide range of temperatures and pH conditions, ensuring reliable performance during processing, storage, and application. Additionally, its nonionic nature minimizes interactions with active ingredients, contributing to formulation flexibility.
Conclusion
Poloxamer 182 is a versatile nonionic surfactant with broad applications in pharmaceuticals, cosmetics, and industrial formulations. Its functions in solubilization, emulsification, and stabilization, combined with benefits such as biocompatibility, chemical stability, and formulation versatility, make it an important excipient and processing aid. The compound continues to support effective formulation development and performance across multiple industries.
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