CAS · 71138-97-1
Product Overview
Hypromellose Acetate Succinate is a high-purity pharmaceutical-excipients supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Property | Specification |
|---|---|
| Grade | USP42 |
| Appearance | Should be white or similar white powder, odorless, tasteless |
| Viscosity | Standard: 3 mPa.s, Range: 80%-120% |
| Acetic acid, succinic acid | 1.0% max |
| Dry weightlessness | 5.0% max |
| Residue on ignition | 0.2% max |
| Heavy metals | 0.001% max |
| Arsenic salt | 0.0002% max |
| Methoxy content | 21.0%-25.0% |
| 2-hydroxypropyl content | 5.0%-9.0% |
| -OCOCH3 content | 7.0%-11.0% |
| -OCOCH2CH2COOH content | 10.0%-14.0% |
Applications
1.Pharmaceutical Industry:
- Solid Dispersion Systems: HPMCAS is extensively used in the formulation of amorphous solid dispersions (ASDs), enhancing the bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs).
- Enteric Coatings: The polymer serves as an effective enteric coating agent, protecting APIs from degradation in the acidic environment of the stomach and ensuring targeted drug release in the intestine.
- Controlled Release Systems: Hypromellose Acetate Succinate can be tailored to provide sustained or delayed drug release, optimizing therapeutic outcomes and minimizing dosing frequency.
2.Nutraceuticals:
- Dietary Supplements: HPMCAS is increasingly used in nutraceutical tablets and capsules to improve the absorption and efficacy of active ingredients, particularly for fat-soluble vitamins and herbal extracts.
3.Specialized Applications:
- Solubility Enhancement: For poorly water-soluble drugs, Hypromellose Acetate Succinate forms a molecular dispersion, creating a stable, bioavailable form of the API.
- Stabilization of Drug Formulations: It prevents crystallization of APIs, ensuring consistency and efficacy throughout the product's shelf life.
Benefits
1.Enhanced Solubility and Bioavailability:
- Amphiphilic Properties: HPMCAS has both hydrophilic and lipophilic characteristics, improving the solubility of hydrophobic APIs.
- Consistent Drug Absorption: By maintaining APIs in an amorphous state, it enhances their dissolution rate and bioavailability.
2.Targeted Drug Delivery:
- Enteric Protection: Its acid-resistant nature ensures drugs are released only after passing through the stomach, protecting sensitive APIs and reducing gastrointestinal side effects.
- Controlled Release: The polymer's properties can be adjusted to control the rate and site of drug release.
3.Versatility in Formulation:
- Compatibility: Hypromellose Acetate Succinate works with a wide range of APIs and excipients, making it a flexible choice for formulators.
- Adaptable Performance: Available in different grades, it can be customized to meet specific formulation needs.
4.Stability and Shelf Life:
- Thermal and Chemical Stability: HPMCAS provides robust protection against environmental factors, ensuring the integrity of sensitive formulations.
5.Cost-Efficiency:
- Effective Usage: Even at low concentrations, HPMCAS delivers reliable performance, making it a cost-effective excipient for advanced drug formulations.
Conclusion
A concise summary and suitability assessment for this product is available on request. Contact our team to discuss whether it fits your process and quality requirements.