CAS · 152751-57-0
Product Overview
Sevelamer hydrochloride is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Appearance | White or light yellow, Crystalline powder |
|---|---|
| Phosphate binding rate (on dried basis) | 5.0 to 7.0 mmol/g |
| Identification | Should give positive reaction IR spectrum should match with reference substance |
| Loss on drying | 8.0% max |
| Residue | 0.2% max |
| Heavy metals | 20 ppm max |
Applications
Sevelamer hydrochloride is primarily used as a phosphate-binding agent in the management of hyperphosphatemia, particularly in patients with chronic kidney disease (CKD) undergoing dialysis. It functions by binding dietary phosphate in the gastrointestinal tract, preventing its absorption and thereby helping to maintain normal serum phosphate levels. Sevelamer hydrochloride is administered orally in the form of tablets or powder for suspension, and it is often included in treatment regimens to reduce the risk of vascular calcification and other complications associated with elevated phosphate levels in CKD patients.
Benefits
The benefits of Sevelamer hydrochloride include its ability to effectively lower serum phosphate without increasing calcium levels, reducing the risk of hypercalcemia commonly associated with calcium-based phosphate binders. It helps prevent secondary complications of CKD, such as bone disorders and cardiovascular calcification, while improving patient outcomes. Sevelamer hydrochloride also exhibits good gastrointestinal tolerability and can reduce low-density lipoprotein (LDL) cholesterol, providing additional cardiovascular benefits. Its non-absorbable nature ensures that its effects are localized to the gastrointestinal tract, minimizing systemic exposure and adverse effects.
Conclusion
Sevelamer hydrochloride is a critical therapeutic agent for controlling hyperphosphatemia in chronic kidney disease patients. Its effectiveness in lowering phosphate levels, favorable safety profile, and additional cardiovascular benefits make it a preferred option over calcium-based binders. By helping to manage phosphate balance and prevent associated complications, Sevelamer hydrochloride plays an essential role in improving the quality of life and clinical outcomes of patients with CKD.
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