CAS · 82410-32-0
Product Overview
Ganciclovir is a high-purity a-api supplied for industrial and specialty chemical applications. Contact our team for specifications, packaging options and lead times.
Product Specifications
| Property | Specification |
|---|---|
| Grade | USP39 |
| Description | White crystalline odourless powder |
| Solubility | Very slightly soluble in water |
| Ultraviolet absorption | 222–252 nm |
| Infrared absorption | Complies |
| Water | 6.0% max |
| Heavy metals | 20 ppm max |
| Residue on ignition | 0.1% max |
| Sterility test | Comply |
| Single impurity | 0.5% max |
| Total impurities | 1.5% max |
| Purity (HPLC) | 98.0%–102.0% |
| Methanol | 3000 ppm max |
| DMF | 800 ppm max |
Applications
1. Treatment of Cytomegalovirus (CMV) Infections
The most critical application of ganciclovir is in the management of CMV, a herpesvirus that can cause severe disease in people with weakened immune systems.
● CMV retinitis: In patients with AIDS, ganciclovir is commonly used to treat CMV-induced inflammation of the retina, which can lead to blindness if untreated.
● Systemic CMV infections: Used for pneumonitis, esophagitis, and colitis in transplant recipients and other high-risk groups.
● Congenital CMV: Investigational and sometimes off-label use includes treatment in neonates with congenital CMV infections, particularly to prevent or reduce hearing loss and developmental delay.
2. Prophylaxis in Organ Transplantation
Ganciclovir丨CAS 82410-32-0 is widely used as a prophylactic agent to prevent CMV infection or reactivation in solid organ and bone marrow transplant recipients.
● Preemptive therapy: In high-risk patients (e.g., CMV-positive donor to CMV-negative recipient), ganciclovir helps reduce the risk of CMV disease, which can otherwise compromise graft survival and patient health.
● Long-term immunosuppression: It is part of preventive regimens for patients on chronic immunosuppressive therapy post-transplant.
3. Treatment of Other Herpesviruses
Though less common, ganciclovir also shows activity against other herpesviruses, including:
● Herpes simplex virus (HSV) types 1 and 2
● Varicella-zoster virus (VZV)
● Epstein-Barr virus (EBV)
● Human herpesvirus-6 (HHV-6)
These applications are generally reserved for resistant cases or co-infections, especially when standard therapies (e.g., acyclovir) are ineffective.
4. Ophthalmic Use – CMV Retinitis Implant
A ganciclovir intraocular implant has been developed to provide localized, sustained release of the drug directly to the eye, particularly beneficial for CMV retinitis.
● Long-term management: Provides targeted treatment while reducing systemic exposure and side effects.
● Vision preservation: Helps maintain vision in patients at risk of blindness due to retinal involvement.
5. Oncology and Experimental Antiviral Research
Ganciclovir丨CAS 82410-32-0 is also used in experimental gene therapy and oncology research, where it functions in combination with viral or suicide gene vectors.
● Suicide gene therapy: In some experimental cancer treatments, ganciclovir is used with the HSV-tk (thymidine kinase) gene, selectively killing cancer cells that express this gene.
● Investigational antivirals: Studied for broader antiviral applications and for use in combination therapies targeting viral latency or resistance.
Benefits
1. High Specificity for Virus-Infected Cells
Ganciclovir丨CAS 82410-32-0 is selectively phosphorylated by a viral enzyme (UL97 kinase) in CMV-infected cells, which leads to targeted inhibition of viral DNA polymerase without broadly affecting healthy cells.
● Reduced collateral toxicity: Compared to earlier antivirals, it offers a more targeted mechanism.
● Effective viral suppression: Reduces viral replication and spread in immunocompromised patients.
2. Established Efficacy in High-Risk Populations
Its proven clinical success in managing life-threatening infections in AIDS patients and transplant recipients makes it a cornerstone therapy.
● Life-saving role: Helps prevent vision loss, systemic infection, and graft failure.
● Versatile delivery: Available in multiple forms-oral, intravenous, and intraocular-for various clinical scenarios.
3. Role in Preventive Medicine
Ganciclovir's use in prophylaxis represents a major advancement in the prevention of opportunistic viral infections, which are a significant cause of morbidity in transplant medicine.
● Reduces hospitalization: Decreases the risk of CMV-related complications.
● Improves transplant outcomes: Contributes to long-term graft and patient survival.
4. Foundation for Newer Antivirals
Ganciclovir has paved the way for newer analogs, such as valganciclovir, which has improved oral bioavailability. However, ganciclovir remains a critical reference compound and is often used when high-dose intravenous therapy is needed.
● Cost-effective alternative: Especially in settings where newer drugs are not available or affordable.
● Established protocols: Well-documented dosage regimens, adverse effects, and monitoring procedures.
Conclusion
Ganciclovir丨CAS 82410-32-0 is a potent antiviral agent with critical applications in the treatment and prevention of CMV infections, particularly in immunocompromised individuals such as HIV/AIDS patients and transplant recipients. Its ability to target viral DNA replication with high specificity offers therapeutic benefit in both acute treatment and long-term prophylaxis. With additional applications in ophthalmology, oncology research, and herpesvirus management, ganciclovir continues to be an essential tool in modern antiviral therapy and clinical virology.
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Conclusion
A concise summary and suitability assessment for this product is available on request. Contact our team to discuss whether it fits your process and quality requirements.